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2008
Eighth Annual Beckman Scholars Symposium
Friday Concurrent Session Speaker
Catherine
L. Drennan, Ph.D.
Associate Professor of Chemistry, Massachusetts Institute of Technology
Structural
Biology in the Post Genomic Era |
Crystallography
is a powerful technique for determining the three-dimensional structures
of proteins. These structures reveal important clues as to how the
protein accomplishes its function, and can provide a framework for
the design of pharmaceuticals. Now in the post genomic era, with the
advances in molecular biology, synchrotron radiation, and computing,
crystallography is used to go beyond a single picture of one protein
from one organism, to elucidate structures of entire enzyme pathways
and to capture "snapshots" of enzymes in action. In this
talk I will summarize our progress toward viewing nature at the atomic
level.
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Catherine
L. Drennan received an A.B. in Chemistry at Vassar College
in 1985 and, following several years of high school teaching, she
returned to graduate school at the University of Michigan. Her thesis
work, under the direction of Professor Martha Ludwig, focused on
the X-ray structure determination of the methylcobalamin-binding
domain of methionine synthase. She received her Ph.D. in Biological
Chemistry in 1995, after which she was a Postdoctoral Fellow with
Professor Douglas C. Rees at the California Institute of Technology.
In 1999 she joined the faculty of the Massachusetts Institute of
Technology as an Assistant Professor of Chemistry, and was promoted
to Associate Professor of Chemistry with tenure in 2005. Her main
research interest is the use of X-ray crystallography to study the
structure and mechanism of metalloproteins. Her awards include the
Searle Scholar Award, ASBMB-Schering-Plough Research Institute Scientific
Achievement Award, an Alfred P. Sloan Fellowship, the Harold E.
Edgerton Faculty Achievement Award, the Dean's Educational and Student
Advising Award, Everett Moore Baker Memorial Award for Excellence
in Undergraduate Teaching, and a Presidential Early Career Award
for Scientists and Engineers. She is a member of the U.S. National
Committee for the International Union of Biochemistry and Molecular
Biology, the Publications Committee of the American Society for
Biochemistry and Molecular Biology, and the Communications Committee
of American Crystallographic Association. At MIT, Cathy teaches
Principles of Freshmen Chemistry 5.111 and is the faculty advisor
of MUBA (MIT Undergraduate Biochemistry Association).
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