Advancing Analysis and Instrumentation for Probing Mechanical Lung Function

Richard Burkhart
Boston University

Recent advances in the fundamental understanding of respiratory physiology have increased the practical significance of measuring lung resistance (RL) and elastance (EL) as an estimation of lung tissue health and airway caliber. A novel technique has previously been developed by our group to measure RL and EL that requires the production of a forced flow of air into and out of the lungs, while simultaneously sampling pressure (Pao) and flow (Qao) at the airway opening. The current system for applying this technique uses antiquated instrumentation and cumbersome software to achieve reliable data. Recent technological advancements will enable one to streamline the instrumentation and software to reduce size and ease operation. The overall goal of this project is to use a compact pneumatic hardware device coupled with a comprehensive software program to control the driving signal, data aquisition, and data analysis of Pao and Qao signals. The system will take advantage of recent advances in programming languages and user-friendly graphical user interface (GUI) controls, including the utilization of industry-standard LabVIEW software for additional flexibility and familiarity. The end point is to allow physicians to utilize RL and EL measurements for a more accurate characterization of the respiratory health of an individual. Additionally, the applications of this system could span from monitoring the lung mechanics of ventilation patients in hospitals to home monitoring for individuals prone to respiratory distress.